Abstract Search

ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushings disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushings syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

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ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushings Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...

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ea0050p267 | Neuroendocrinology and Pituitary | SFEBES2017

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Tobin Jake , White Louisa , Koulouri Olympia , Bashari Waiel , Powlson Andrew , Gillett Daniel , Cheow Heok , Gurnell Mark

Background: Cross-sectional imaging (e.g. CT/MRI) can not always reliably identify the site of ACTH secretion in Cushings disease (CD) or the ectopic ACTH syndrome (EAS). We report our experience of localising the source of ACTH-dependent Cushings syndrome, using functional imaging with 11C-methionine positron emission tomography (Met-PET).Methods: Forty consecutive patients with: (i) de novo ...

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ea0050p279 | Neuroendocrinology and Pituitary | SFEBES2017

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

White Louisa , Tobin Jake , Koulouri Olympia , Powlson Andrew , Bashari Waiel , Koo Brendan , Gurnell Mark

Background: BIPSS is considered the gold-standard procedure for differentiating autonomous pituitary [Cushings Disease (CD)] and ectopic ACTH syndrome (EAS) sources of ACTH hypersecretion. A basal (i.e. unstimulated) pituitary:peripheral ACTH ratio >2, and/or a CRH stimulated pituitary:peripheral ACTH ratio >3, have been proposed as indicative of CD, with a range of sensitivities and specificities cited in the literature. Ad...

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Endocrine Abstracts

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

BiosciAbstracts

Endocrine Abstracts

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

11C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

Bilateral Inferior Petrosal Sinus Sampling (BIPSS) reliably differentiates pituitary from ectopic Cushing’s syndrome, but does not predict pituitary tumour location, especially when lateralizing to the right

BiosciAbstracts

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.

¹¹C-methionine PET can aid localisation of the source of ACTH-dependent Cushing’s syndrome in patients with equivocal or negative conventional imaging.